THU Health Care Report: MCW faculty help create more nuanced framework for categorizing traumatic brain injury

From WisPolitics.com/WisBusiness.com …

— Medical College of Wisconsin faculty were involved in creating a more nuanced framework for categorizing traumatic brain injury, which was detailed in a recently published study

Through an initiative of the National Institutes of Health-National Institute of Neurological Disorders and Stroke, the college’s faculty members helped develop the new framework that goes beyond the traditional “mild, moderate or severe” categories. 

By incorporating various elements such as clinical factors, biomarkers, imaging and “modifiers” such as pre-existing health conditions, the new framework aims to capture the complexity of traumatic brain injury. 

“While current categories for TBI can still be helpful in early clinical treatment, they were established in 1974, and don’t take into account the many advances our field has achieved over the last 50 years such as precise neuroimaging and biomarkers in your blood that can confirm TBI,” MCW’s Dr. Lindsay Nelson said in a release on the study. 

The older framework, called the Glasgow Coma Scale, doesn’t reflect differences in how patients recover from a brain injury, according to MCW. The announcement notes some patients with mild injury can have persistent symptoms, and others classified as severe can have a quicker recovery. 

Other MCW faculty tapped for the NIH’s TBI Classification and Nomenclature Initiative include Drs. Michael McCrea and Timothy Meier of the college’s Department of Neurosurgery and Dr. Danny Thomas, an emergency medicine doctor in the MCW Department of Pediatrics. 

McCrea, who co-directs the college’s Center for Neurotrauma Research, was on the NIH initiative’s steering committee and was a co-senior author for the study that was published in the latest issue of The Lancet Neurology. 

See more in the release below. 

— Children’s Wisconsin has announced plans to open a new mental health walk-in clinic in Green Bay, its third in the state. 

It will be located within the Bellin Psychiatric Center, serving patients in Brown and Oconto counties and elsewhere in the region. The announcement notes an opening date hasn’t been chosen yet and will depend on “recruitment of providers and other team members needed to staff the clinic.” 

The hospital previously opened its first mental health walk-in clinic in Milwaukee in 2022, and a second clinic in Kenosha last year. More than 3,400 pediatric patients have received services since the first clinic opened, according to yesterday’s announcement. Most of these kids were seen for anxiety, depression, trauma concerns and school avoidance. 

Amy Herbst, vice president of mental and behavioral health at Children’s Wisconsin, points to the growing mental health “crisis” facing youth in the state. She says the clinic is a great place to start for kids who don’t have a provider, or for those who can’t wait for the next available appointment with their existing provider. 

“We can lend support in the moment and establish a treatment plan going forward,” Herbst said in a statement. “Sometimes kids need help now, and that’s what these mental health walk-in clinics provide.” 

See the release below. 

— Madison-based Archeus Technologies has gotten FDA clearance for an investigational new drug application for its prostate cancer treatment. 

The company recently announced the agency’s approval allows it to begin a Phase 1 clinical trial later this year for ART-101, a receptor-based targeting molecule. This follows last year’s FDA clearance of the company’s lead therapeutic candidate and a companion diagnostic molecule. 

“This IND clearance marks an important milestone for Archeus as we prepare to initiate the first of multiple clinical trials set to begin this year from our broader portfolio of differentiated radiopharmaceutical assets for difficult-to-treat cancers,” CEO Evan Sengbusch said in a statement. 

See more at Madison Startups

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Press Releases

– Medical College of Wisconsin: Researchers aiming to rewrite how brain injuries are evaluated and treated 

– Children’s Wisconsin: To open mental health walk-in clinic in Green Bay