UW-Madison: New NIH funded initiative will examine Alzheimer’s disease in people Down syndrome

MADISON – A team of researchers at the University of Wisconsin-Madison is part of a new multi-institution effort to better understand Alzheimer’s disease in adults with Down syndrome.

Adults with Down syndrome are at high risk for developing Alzheimer’s disease beginning in their late 40s, because of their unique biology. The vast majority will eventually develop the disease by their late 60s, but signs of the disease may be evident when they are much younger.

The new effort, funded by up to $109 million from the National Institutes of Health over the next five years, is focused in part on identifying these early biological signatures.

The research teams will assess and examine a wide range of data from participants, who will take part every 16 months for up to four visits. This includes biomarkers found in plasma, sweat and other biological fluids; genetic factors; brain imaging; and cognitive and psychological function.

“Today, adults with Down syndrome are living longer and leading more productive lives than in the past, which is wonderful,” says Waisman Center investigator and medical physics and psychiatry Professor Bradley Christian, co-director of the national study and leader of the UW-Madison team. “Unfortunately, this is being accompanied by a much higher prevalence of Alzheimer’s disease in adults with Down syndrome in their 50s and 60s.”

More than 75 percent of people with Down syndrome who live to age 65 will develop Alzheimer’s disease and the NIH estimates that more than 5 million people in the United States are living with the neurodegenerative condition, including more than 1 in 10 people over age 65.

“The study is critical for individuals with Down syndrome because they have a really heightened risk for Alzheimer’s disease,” says Sigan Hartley, study co-researcher, a Waisman Center investigator and School of Human Ecology professor of human development and family studies. “Alzheimer’s disease can affect any of us and so what we learn from this study has the potential to help everyone.”

In fact, the researchers hope the expanded study will “lay out a path to better inform prevention and treatment trials for Alzheimer’s disease in adults with Down syndrome that can ultimately be extended to the general population,” says Christian, an Alzheimer’s Disease Research Center affiliate.