Contact: Ian Clark
MADISON, Wis. — The Institute for Clinical and Translational Research (ICTR) at the University of Wisconsin-Madison has released its list of those awarded grants for research and the improvement of care. Type I awards address basic laboratory investigations, patient-oriented research and innovations in technology and biomedical devices. Type II grants include improvements in clinical practice and community health.
Awardees, primarily from the UW School of Medicine and Public Health (UW SMPH), tackle issues as varied as using magnetic resonance imaging near metallic implants, Alzheimer’s drug delivery techniques, supporting individuals with mild cognitive decline, and educating at-risk seniors in fall prevention.
For details about Type I collaborators, project summaries and partners, go online at https://ictr.wisc.edu/node/1261. For complete details about Type II collaborators, project summaries and partners, go online at https://ictr.wisc.edu/node/1258.
ICTR Type 1 grants ($50,000)
Advanced Magnetic Resonance Methods for Imaging Near Metallic Implants
Principal Investigator: Nathan Artz, SMPH
This overall goal of the research is to develop novel methods for distortion-free MRI near metallic implants.
Genomic Studies of Circulating Tumor Cells: Novel Metastatic Biomarkers
PI: Joshua Lang, SMPH
The team is using a novel platform to capture circulating tumor cells via fluid biopsy and isolate nucleic acids for assay to identify and predict therapeutic response and resistance to anti-cancer therapies.
A Close-looped Neural Activity-triggered Stroke Rehabilitation Device
PI: Vivek Prabhakaran, SMPH
This proposal investigates a new non-invasive method that aims to restore brain function while improving corresponding motor function for stroke patients.
Neural Basis and Treatment of Youth Post-traumatic Stress Disorder
PI: Ryan Herringa, SMPH
This pilot study aims to address knowledge gaps in pediatric PTSD by examining baseline differences in emotion regulation circuitry in pediatric PTSD compared to healthy youth.
Congenital Diaphragmatic Hernia: Genetic Basis and Stem Cell Therapy
PI: David McCulley, SMPH
Researchers propose to use a mouse model to investigate the role of genetic mutations on lung development and pulmonary vasculature.
In Depth Delineation of FcyRIIc and FcyRIIIa Genotypes and Potential Clinical Implications
PI: Paul Sondel, SMPH
The team will develop a new method to determine differences in patient genotypes and correlate genetic differences with the patient’s innate immune system to mediate clinical benefit.
A porcine model to study calcium oxalate urolithiasis: From the Barn to the Bedside
PI: Kris Penniston, SMPH
Researchers will address the question of whether oxalate restriction decreases urinary oxalate excretion and calcium oxalate stone risk, while generating evidence regarding nutrition therapy for stone prevention.
Characterization of a Novel Block to HIV-1 Replication
PI: Nathan Sherer, SMPH
This study aims to elucidate new details of HIV viral replication and potentially inform the development of antiviral strategies capable of disrupting the virus.
Transgenic Marmosets for Translational Research
Thaddeus Golos, SMPH
The long-term goal of this work will provide investigators with transgenic and genetically modified common marmosets as platforms for translational research.
HTS on Smooth Muscle vs Endothelial Cells for Anti-Restenosis Drugs
PI: K Craig Kent, SMPH
This work will use a high throughput screening strategy to discover drugs that selectively and potently inhibit SMC proliferation, while leaving growth of endothelial cells unaffected.
Novel Methods Pilot Grant Award
Novel Statistical Methods for Cancer Risk Prediction
PI: Richard Chappell, SMPH
This work proposes to use strategies that build on recent developments in statistical learning, and enable a systematic investigation of the large number of risk factors and interactions, leading to improved diagnostic recommendations.
ICTR co-funding of 2012 UW Alzheimer’s Disease Research Center Pilot
Toward the Development of a Noninvasive Immunotherapy for Alzheimer’s Disease: Intranasal Targeting of IgG to the Brain
PI: Robert Thorne, Pharmacy
The ability to deliver proteins as large as IgG into the brain using the non-invasive intranasal approach would represent a significant advance that could potentially offer an alternative or supplement approach to IV antibody applications for AD.
ICTR Type II Awards
Pilot Awards ($75,000, 12 months)
Living Well with Memory Partners
Principal Investigator: Carey Gleason, assistant professor, SMPH
Project intends to strengthen social connections, building skills and self-efficacy to manage memory loss through workshops for older African-Americans with mild cognitive impairment.
Exploring How Hospital Nurses Perceive Patients Identified as Fall Risk and Influence on Decisions to Walk Patients
PI: Barbara King, assistant professor, nursing
The project intends to develop an understanding of how nurses perceive patients and approach care for fall-risk patients, to ultimately reduce overall fall numbers.
Better, Safer Care through Clear Communication
PI: Paul Smith, professor, SMPH
This pilot will use adult learning theory to develop and refine a workshop with four interactive sessions designed to enhance caregiver skills and confidence to communicate more effectively with health care professionals.
A Community-based, Behavioral Intervention to Improve Screening for Hepatitis C among High-risk Young Adults in Wisconsin
PI: Ryan Westergaard, assistant professor, SMPH
The goal is to test the effectiveness of a community-based project to increase the number of people who know their hepatitis C status and stop behaviors that can spread hepatitis C infection to others in the community.
Patient-Centered Outcomes Research Awards ($100,000 for 12 months)
Engaging Stakeholders to Deliver Family-centered Diabetes Self-management Resources
PI: Elizabeth Cox, assistant professor, SMPH
Researchers will gather input directly from families and children with type 1 diabetes, providing the basis for incorporating stakeholder perspectives into research on how to improve outcomes.
Expanding the Role of the Community Pharmacist in Falls Prevention
PI: David Mott, professor, pharmacy
This project will create a screening tool and referral process to link at-risk older adults with local pharmacists, helping community health organizations overcome structural and procedural barriers to promote older adults’ access to care.
Reducing Readmission after Complex Cancer Surgery: A Human Factors and Systems Engineering Approach
PI: Sharon Weber, professor, SMPH
The goals of the project include assessing the cause of readmission from the patient and caregiver’s perspective and assessing the clinical risk factors associated with increased risk of readmission.
Dissemination / Implementation Research Award ($150,000 for 24 months)
“Stepping On” to Pisando Fuerte: Adapting an Evidence-based Falls Prevention Program for Latino Seniors
PI: Jane Mahoney, professor, SMPH
To remedy an existing health disparity, we will develop and test a fall prevention program that is adapted to Hispanic culture and language — Pisando Fuerte.